Every person has a unique internal physiologic environment and can therefore experience different results with various medications. One person’s response to a dose of edible cannabis can vary significantly from the next, even more so than other medications or herbs. Why?
Several factors are involved, including previous history of cannabis use, gastrointestinal factors, and the function/sensitivity of one’s endocannabinoid system. Approximately 3% of patients are ultra-sensitive to THC and do well with very low doses (e.g., 1 mg).